Zoletil 100
Active substance
ATC code
Species
Dogs and cats.
Indications
General anaesthesia.
Dose to be administered and administration route
Intramuscular or intravenous use.
Dosage:
The content of the lyophilisate vial is to be diluted in 5 ml of the attached solvent.
The dosage is expressed in mg of the product, on the understanding that the reconstituted product is at a concentration of 100 mg per ml and contains 50 mg of tiletamine per ml and 50 mg of zolazepam per ml.
When the product is administered intramuscularly (unable to stand in 3 to 6 minutes) or intravenously (unable to stand in less than one minute), the recommended therapeutic dosages are the following:
|
IN DOGS |
Intramuscular route |
Intravenous route |
|
Tests and procedures causing little pain |
7 to 10 mg/kg bw 0.07 to 0.1 mL/kg bw |
5 mg/kg bw 0.05 mL/kg bw |
|
Minor surgical procedures, anaesthesia of short duration |
10 to 15 mg/kg bw 0.1 to 0.15 mL/kg bw |
7.5 mg/kg bw 0.075 mL/kg bw |
|
Painful interventions |
15 to 25 mg/kg bw 0.15 to 0.25 mL/kg bw |
10 mg/kg bw 0.1 mL/kg bw |
|
IN CATS |
Intramuscular route |
Intravenous route |
|
Tests and procedures causing little pain |
10 mg/kg bw 0.1 mL/kg bw |
5 mg/kg bw 0.05 mL/kg bw |
|
Orthopaedic operation |
15 mg/kg bw 0.15 mL/kg bw |
7.5 mg/kg bw 0.075 mL/kg bw |
Please refer also to sections “Adverse reactions” and/or “Overdose” since adverse reaction might occur at therapeutic doses.
Intravenous injections to be repeated, if needed, at between 1/3 and 1/2 of the initial dose but the total dosage should not exceed 26.4 mg/kg bw (0.264 mL/kg bw).
The individual response to Tiletamine-Zolazepam will vary depending upon several factors. Therefore, the dosage should be adjusted, at the discretion of the practitioner, based on the species, the type and duration of surgical procedure, the other concomitant medication (pre-anaesthetic and other anaesthetic agents) and the health status of the animal (age, obesity, severe organic deficiencies, state of shock, debilitating diseases).
Duration of anaesthesia: 20 to 60 minutes depending on dose.
The product should not be used as sole anaesthetic agent for painful operations. For these operations the product should be combined with an appropriate analgesic.
Pre-surgical preparation:
As for all anaesthetics animals should be fasted for at least 12 hours before anaesthesia.
In dogs and cats, the use of atropine subcutaneously, 15 minutes before injection, may be considered.
Recovery period:
Analgesia lasts longer than surgical anaesthesia. Return to normal is progressive and can last 2 to 6 hours in a calm environment (avoid excessive noise and light). Recovery may be delayed due to an overdose in obese, old or debilitated animals.
Adverse reactions
Pain upon injection has been reported very rarely. This is most prevalent in cats. The following signs have been reported very rarely, mainly during the awakening phase in the dog, and during surgery and the awakening phase in the cat;
- Neurological signs – prostration, convulsions, coma.
- Cardio-respiratory signs – dyspnoea, tachypnoea, bradypnoea, tachycardia, cyanosis, have been noted at doses of 20 mg/kg and above.
- Certain systemic signs – hypothermia, hyperthermia, pupillary disorder, hypersalivation, hypersensitivity to external stimuli, agitation, vocalisation.
Prolonged anaesthesia and difficulties when awakening (with myoclonus, restlessness, ataxia, paresis, etc.) have been observed in the recovery phase. All reactions are reversible and disappear once the active substance is eliminated from the body.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
