Propofol-Lipuro
Active substance
ATC code
Species
Dogs and cats.
Indications
A short–acting, intravenous, general anaesthetic for procedures of short duration, lasting up to five minutes.
For induction and short-term maintenance of general anaesthesia using incremental doses to effect.
For induction of general anaesthesia where maintenance is provided by inhalation anaesthetics.
Dose to be administered and administration route
Administration: By intravenous injection.
Before opening the container, the product should be inspected visually for the absence of visible droplets or extraneous foreign particles and discarded if present. The container should be shaken gently but thoroughly before opening.
Induction: The induction dose is computed according to bodyweight and may be administered to effect over a period of 10 – 40 seconds. Alternatively, the computed dose may be given in full as a single bolus. The induction dose is reduced by the use of premedicants.
It should be noted that the dose rates shown are for guidance and in practice the dose rate should be based on response.
The average induction dose for dogs and cats, either unpremedicated or when premedicated with a non alpha-2-agonist tranquilliser such as acepromazine, is as follows:
Maintenance by Propofol-Lipuro Vet 10 mg/ml : Where anaesthesia is maintained by incremental injections, the dose rate will vary between animals. Incremental doses should be given to effect. Experience in clinical trials has shown that doses of around 1ml per 4.0 – 8.0 kg bodyweight sustain anaesthesia for periods of up to five minutes.
Maintenance by inhalation agents: Where inhalation agents are used to maintain general anaesthesia, clinical experience indicates that there may be a need to use a higher initial concentration of inhalation agent than is normally the case following induction with barbiturate agents such as thiopentone.
The emulsion should not be mixed with other therapeutic agents or infusion fluids prior to administration.
Propofol-Lipuro Vet 10 mg/ml does not contain an antimicrobial preservative. It should be used immediately after opening. Any product remaining in the container following withdrawal of the required dose should be discarded.
Continuous and prolonged exposure may lead to slower recovery, particularly in cats.
Adverse reactions
Side-effects during induction, maintenance and recovery are uncommon. Induction is generally smooth, with minimal evidence of excitation. During the recovery phase, vomiting and evidence of excitation have been observed in a small proportion of animals.
In clinical trials in cats and dogs, transient apnoea during induction has been observed frequently. In cats, sneezing, occasional retching and a paw/ face licking characteristic during recovery have been observed in a small proportion of cases.
If panting is evident before induction, it may continue throughout the subsequent periods of anaesthesia and recovery.
Inadvertent perivascular administration rarely causes local tissue reactions.
Repeated anaesthesia with propofol in cats may cause oxidative injury and Heinz body formation. Recovery may also become prolonged. Limiting repeated anaesthesia to intervals of more than 48 hours will reduce the likelihood.
Similar products
Showing 2 of 2 results
Propofol-Lipuro
