Coliprotec F4/F18
Active substance
ATC code
Species
Pigs.
Indications
For active immunisation of pigs from 18 days of age against enterotoxigenic F4positive and F18-positive Escherichia coli in order to:
- reduce the incidence of moderate to severe post-weaning E. coli diarrhoea (PWD) in infected pigs;
- reduce the faecal shedding of enterotoxigenic F4-positive and F18-positive E. coli from infected pigs.
Onset of immunity: 7 days after vaccination
Duration of immunity: 21 days after vaccination
Dose to be administered and administration route
Oral use.
Vaccination schedule: administer a single dose orally from 18 days of age.
All materials used in preparing and administering the vaccine must be free of antimicrobials, detergent or disinfectant residues to prevent inactivation.
The reconstituted vaccine is a transparent to opaque white-yellowish suspension depending on the volume of water used for dilution.
Vaccination by drench application:
- 50-dose presentation: Reconstitute the lyophilisate by adding 10 ml of water to the vial. Shake well and transfer the suspension into a graduated container, mix again with water to complete to a total volume of 100 ml. Shake well and use within 4 hours. Administer a single 2 ml dose orally to pigs, irrespective of body weight.
- 200-dose presentation: Reconstitute the lyophilisate by adding 20 ml of water to the vial. Shake well and transfer the suspension into a graduated container, mix again with water to complete to a total volume of 400 ml. Shake well and use within 4 hours. Administer a single 2 ml dose orally to pigs, irrespective of body weight.
Vaccination via the drinking water system:
The drinking water systems have to be cleaned and intensively rinsed with untreated water to avoid any residues of antimicrobials, detergents or disinfectants.
Withhold drinking water supply for 1 to 2 hours prior to the planned vaccination to stimulate drinking of the vaccine suspension.
Reconstitute the lyophilisate by adding 10 ml (50-dose presentation) or 20 ml (200dose presentation) of water to the vial. Shake well.
The final suspension containing the vaccine should be consumed within 4 hours after preparation. Provide enough space so that all pigs can drink the required amount. The actual amount of water consumed may however vary considerably depending on several factors. Therefore, it is recommended to assess the actual water intake during a 4-hour time period the day before vaccination. Alternatively, refer to the following table:
Body weight (kg) | Water consumption (litres) in a 4-hour time period | ||
1 pig | 50 pigs | 200 pigs | |
Up to 4.5 | 0.11 litres | 5.5 litres | 22 litres |
4.6 to 6.8 | 0.17 litres | 8.5 litres | 34 litres |
6.9 to 9.0 | 0.23 litres | 11.5 litres | 46 litres |
- For administration using bowls or tanks, dilute the reconstituted vaccine in the volume of water that the pigs will drink during a 4-hour time period.
- For administration through water lines using a dosing pump (proportioner), dilute the reconstituted vaccine in the needed volume of the dosing pump stock solution. The volume of stock solution is calculated using the volume of water that the pigs will drink during a 4-hour time period multiplied by the dosing pump rate (in decimal). As an example, for a 4-hour consumption of 22 litres and a dosing pump rate of 1%, the volume of the stock solution should be 22 litres x 0.01 = 220 ml.
In case of concerns about the presence of disinfectant residues in the drinking water, such as chlorine, it is recommended to add skimmed milk powder as a stabilizer into the drinking water prior to adding the vaccine. The final concentration of the skimmed milk powder should be 5 g/litre.
Adverse reactions
No adverse reactions have been observed.
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| Art. Nr. | 00879/5000 |
